Pitchappan, R. M. ; Amutha, S. ; Mahendran, V. ; Brahmajothi, V. ; Shankar Kumar, U. ; Balakrishnan, K. ; Shantha Kumari, R. ; Sashidhar, M. ; SamalRaj, ; Manuel, May ; Indra Raja, V. (1993) Frequency of HLA antibodies in South India Journal of Biosciences, 18 (3). pp. 373-380. ISSN 0250-5991
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Official URL: http://www.ias.ac.in/jarch/jbiosci/18/373-380.pdf
Related URL: http://dx.doi.org/10.1007/BF02702995
Abstract
Sera from 4088 pregnant women (649 antenatal bleeding and 3439 post-partum bleeding) living in Madurai, were collected and screened for anti-HLA. A, B and DR antibodies. 696 of them were screened for anti-HLA DR antibodies. Ten per cent (65/649) of antenatal sera and 13 4% of post-partum sera (463/3439) were positive for HLA A and B antibodies: nonetheless the percentage of monospecific sera were almost the same in both. Screening for HLA DR antibodies were carried out using platelet absorption in test tray technique: seventy three of 696 (10.5%) were positive. The incidence of anti-HLA A, B antibodies correlates to the allelic frequencies in the population. Thus in India, collection and screening post-partum haemorrhage is the simplest and cost effective method of acquiring polyclonal sera for routine laboratory and diagnostic use.
Item Type: | Article |
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Source: | Copyright of this article belongs to Indian Academy of Sciences. |
Keywords: | HLA; anti-HLA Antibodies; Post-partum; Pregnancy |
ID Code: | 31913 |
Deposited On: | 25 Apr 2011 13:28 |
Last Modified: | 17 May 2016 14:40 |
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