Rajendiran, Venugopal ; Palaniandavar, Mallayan ; Swaminathan, Palanisami ; Uma, Lakshmanan (2007) Cleavage of proteins by a mixed-ligand copper(ii) phenolate complex: hydrophobicity of the diimine coligand promotes cleavage Inorganic Chemistry, 46 (25). pp. 10446-10448. ISSN 0020-1669
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ic700823q
Related URL: http://dx.doi.org/10.1021/ic700823q
Abstract
The mixed-ligand copper(II) complex [Cu(tdp)(tmp)](ClO4), where H(tdp) is 2-[(2-(2-hydroxyethylamino)ethylimino)methyl]phenol and tmp is 3,4,7,8-tetramethyl-1,10-phenanthroline, exhibits cleavage of the proteins bovine serum albumin and lysozyme, producing approximately 5 and 4 kDa protein fragments respectively within a few minutes at micromolar concentrations. The hydrophobic tmp ligand recognizes the hydrophobic site and enhances protein binding and cleavage even at physiological pH and temperature.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 30968 |
| Deposited On: | 27 Dec 2010 06:54 |
| Last Modified: | 05 Mar 2011 05:32 |
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