Models for enzyme-copper-nucleic acid interaction 1H NMR line broadening study of the interaction of some copper complexes with cytidine

Palaniandavar, Mallayan (1989) Models for enzyme-copper-nucleic acid interaction 1H NMR line broadening study of the interaction of some copper complexes with cytidine Biological Trace Element Research, 21 (1). pp. 41-48. ISSN 0163-4984

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Official URL: http://www.springerlink.com/content/e82t6450l33650...

Related URL: http://dx.doi.org/10.1007/BF02917235

Abstract

Sodium (salicylideneglycylglycinato) copper(II), bis(2,9-dimethyl-1, 10-phenanthroline)copper (II), and (1,5-bis (benzimidazol-2-yl)-3-thiapentane) copper(II) were interacted with cytidine in D2O. For all the complexes, the broadening of the1H signals of cytidine is found to be in the order H(5)>H(6)>H(1'); this suggests the binding of N (3) and O2 sites of cytidine to copper. The possibility that the ribose moiety is also involved in coordination cannot be ruled out. The complete broadening of the H(5) signals for the last complex above is because of the coordinative unsaturation of the complex. It has been concluded that steric factors and coordinative unsaturation in athe complexes affect the extent of interaction with cytidine.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Enzyme-copper-nucleic Acid Interaction; 1H NMR; Copper Complexes; Cytidine
ID Code:30959
Deposited On:27 Dec 2010 06:55
Last Modified:27 Dec 2010 06:55

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