Acute encephalopathy in children in Nagpur: similarity to Reye's syndrome

Abstract

The clinical, laboratory and histopathological features of the Nagpur encephalopathy syndrome and those of Reye's syndrome have been reviewed and found to be strikingly similar. Microvesicular fatty infiltration of hepatic parenchymal cells characteristic of Reye's syndrome was seen in two of three liver specimens collected at autopsy from cases of the Nagpur encephalopathy syndrome. Therefore we suggest that this illness is Reye's syndrome, and not heat stroke as has been suggested earlier by some investigators.