Enantioselective total synthesis of the novel antiproliferative metabolite (+)-hexacyclinol

Mehta, Goverdhan ; Roy, Subhrangsu (2008) Enantioselective total synthesis of the novel antiproliferative metabolite (+)-hexacyclinol Tetrahedron Letters, 49 (9). pp. 1458-1460. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2008.01.014

Abstract

An enantioselective total synthesis of the novel bioactive epoxyquinone natural product (+)-hexacyclinol, exhibiting promising growth inhibiting activity against cancer cell lines, has been accomplished from a readily available chiron derived from the Diels-Alder adduct of cyclopentadiene and p-benzoquinone.

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Deposited On:18 Dec 2010 05:35
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