Strategy for cyclopentenone annulation of olefins: a general protocol for bicyclo [n.3.0] enone synthesis

Mehta, Goverdhan ; Rao, K. Srinivas (1984) Strategy for cyclopentenone annulation of olefins: a general protocol for bicyclo [n.3.0] enone synthesis Tetrahedron Letters, 25 (17). pp. 1839-1842. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(01)90055-3

Abstract

Several bicyclic α -chloro enones obtained through Greene annulation of cyclic olefins are shown to undergo efficient, two step, enone transposition via Luche reduction and aq. formic acid treatment. Application of this methodology to the formal synthesis of exaltone® and (±)-muscone is described.

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