Enantioselective total synthesis of bioactive natural product (+)- Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation

Mehta, Goverdhan ; Shinde, Harish M. (2005) Enantioselective total synthesis of bioactive natural product (+)- Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation Chemical Communications (29). pp. 3703-3705. ISSN 1359-7345

Preview

PDF - Publisher Version
260kB

Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2005...

Related URL: http://dx.doi.org/10.1039/B505264E

Abstract

The total synthesis of the bioactive natural product (+)-Sch 642305 has been achieved from a readily available chiral building block using an RCM protocol to construct the key decalactone moiety; our approach is notable for its built-in flexibility and is diversity oriented.

Item Type:	Article
Source:	Copyright of this article belongs to Royal Society of Chemistry.
ID Code:	29088
Deposited On:	18 Dec 2010 05:37
Last Modified:	17 May 2016 12:03

Repository Staff Only: item control page