Mehta, Goverdhan ; Shah, Shailesh R. ; Venkateswarlu, Yenamandra (1994) Total synthesis of novel xanthone antibiotics (±)-cervinomycins A1, and A2 Tetrahedron, 50 (40). pp. 11729-11742. ISSN 0040-4020
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/S0040-4020(01)85666-0
Abstract
A total synthesis of novel heptacyclic antibiotics cervinomycin A1 1 and A2 2 following a convergent approach is reported. The cornerstone of our strategy was the construction of the central ring D through photochemical electrocyclization. The oxazolo-isoquinolinone fragment (ABC rings) 7 and the xanthone fragment (EFG rings) 8 were assembled through relatively straightforward synthetic protocols and coupled through a Wittig reaction to give 6 and set up the key photocyclization. Our successful approach to 1 and 2 can be readily adapted to the synthesis of analogues of these interesting antibiotics.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 29026 |
Deposited On: | 18 Dec 2010 05:41 |
Last Modified: | 06 Mar 2011 14:02 |
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