Total synthesis of (±)- Merrilactone A

Mehta, Goverdhan ; Robindro Singh, S. (2006) Total synthesis of (±)- Merrilactone A Angewandte Chemie International Edition, 118 (6). pp. 953-955. ISSN 1433-7851

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/anie.20...

Related URL: http://dx.doi.org/10.1002/ange.200503618

Abstract

Merrily, merrily: A total synthesis of the pentacyclic sesquiterpenoid merrilactone A starting from 2,3-dimethyl-2-cyclopentene-1,4-dione has been achieved with good stereo- and regioselectivity. Merrilactone A exhibits impressive neurotrophic activity and may be important for the development of therapeutic drugs for neurodegenerative disorders.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Diastereoselectivity; Natural Products; Neurotrophic Agents; Terpenoids; Total Synthesis
ID Code:28954
Deposited On:18 Dec 2010 05:46
Last Modified:01 Mar 2011 11:32

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