Mehta, Goverdhan ; Umarye, Jayant D. (2002) Studies toward the total synthesis of diterpene antibiotic guanacastepene a: construction of the hydroazulenic core Organic Letters, 4 (7). pp. 1063-1066. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol017098m
Related URL: http://dx.doi.org/10.1021/ol017098m
Abstract
As a part of studies aimed toward the total synthesis of biologically important natural product guanacastepene A of contemporary interest, a new and concise route to a fully functionally endowed hydroazulenic core is delineated. The strategy involves the building of the requisite stereochemical features on a endo-tricyclo[5.2.1.02,6]decane matrix and excision of the five-membered ring through a retro-Diels-Alder reaction. Generation of the seven-membered ring to access the hydroazulenic framework was achieved employing ring closure metathesis (RCM) reaction as the key step.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 28934 |
Deposited On: | 18 Dec 2010 05:47 |
Last Modified: | 18 Dec 2010 05:47 |
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