Polycyclitols: synthesis of novel carbasugar and conduritol analogues as potential glycosidase inhibitors

Mehta, Goverdhan ; Ramesh, Senaiar S. (2001) Polycyclitols: synthesis of novel carbasugar and conduritol analogues as potential glycosidase inhibitors Tetrahedron Letters, 42 (10). pp. 1987-1990. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(01)00050-8

Abstract

Stereoselective syntheses of a new family of hydrindane based bicyclitols with seven hydroxyl groups in a diverse stereochemical array have been accomplished from readily available building-blocks. One of the bicyclitols 12 has been found to exhibit moderate a-glucosidase inhibitory activity in enzymatic assays.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Cyclitols; Carbohydrate Mimetics; Enzyme Inhibitors; Osmylation
ID Code:28931
Deposited On:18 Dec 2010 05:47
Last Modified:18 Dec 2010 05:47

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