Varughese, K. I. ; Aimoto, S. ; Kartha, G. (1986) Calcium binding cyclic hexapeptide: Crystal structure of cyclo-(L-prolyl-glycyl)3 calcium complex International Journal of Peptide and Protein Research, 27 (2). pp. 118-122. ISSN 0367-8377
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...
Related URL: http://dx.doi.org/10.1111/j.1399-3011.1986.tb01800.x
Abstract
The synthetic cyclic hexapeptide (L-prolyl-glycyl)3 forms a 2 : 1 complex with Ca2+ ion. The cation is sandwiched between the two peptide molecules. The gly-cyl carbonyls from each of the peptides are octahedrally coordinated to the cation with an average calcium oxygen coordination distance of 2.26Å. Both the molecules coordinating to the calcium ion have three fold symmetry, but show significant conformational differences. In one of the peptides of the sandwich, the alternate carbonyls point to the opposite sides of the peptide ring while in the other, all the six carbonyls point to the same side of the ring. Three N-H…O hydrogen bonds between the peptides add to the stability of the sandwich.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Munksgaard International Publishers. |
| Keywords: | Cyclic Hexapeptide; Ion Binding; Three Fold Symmetric Conformation; X-ray Crystallography |
| ID Code: | 28705 |
| Deposited On: | 15 Dec 2010 11:41 |
| Last Modified: | 04 Jun 2011 08:48 |
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