Probable role of androgen in the regulation of the uropygial gland

Abstract

The hormonal regulation of the uropygial gland was investigated after administration of testosterone to adult pigeons of both sexes, by prepubertal castration in pigeons and ducks, and by postpubertal castration and replacement therapy of testosterone in adult castrate pigeons. The investigation was based on gravimetric, histological, and mitotic studies. Testosterone treatment elicited stimulation of the uropygial gland in intact birds. This has been accomplished by hyperplasia, accelerated cell differentiation (through lipogenesis), and moderate rise in cell loss. Prepubertal and postpubertal castration by surgical means provoked a depression in the activity of the uropygial gland. The glandular inactivity was evidenced by hypoplasia and retarded lipoidal output concomitant with accelerated rate of cell loss. Replacement with testosterone restored the gland to a normophysiological condition. It is concluded that androgen normally contributes to regulation of the uropygial gland in male birds.