Taranath Shetty, K. ; Naik, P. M. ; Mahadevan, P. R. (1990) A specific colorimetric assay for Dapsone in biological fluids Indian Journal of Clinical Biochemistry, 5 (2). pp. 101-109. ISSN 0970-1915
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Official URL: http://www.springerlink.com/content/d3l3360j313224...
Related URL: http://dx.doi.org/10.1007/BF02873496
Abstract
The original Bratton and Marshall method for sulfanilamide assay has been modified for differential assay of Dapsone even in the presence of other diazotisable compounds. The property of Dapsone diazo derivative to precipitate out upon its coupling with N-(1-naphthyl) ethylene diamine has been taken advantage to differentiate this sulphone from that of other diazotisable compounds. The present assay method also enables one to assay free DDS and its acid labile metabolites in biological samples even in the presence of other diazotisable compounds. The use of the organic solvent to extract the azo colour complex renders greater sensitivity and specificity for DDS assay.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to All India Institute of Medical Sciences. |
| ID Code: | 27656 |
| Deposited On: | 10 Dec 2010 11:53 |
| Last Modified: | 10 Jun 2011 06:45 |
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