Rosemary, M. J. ; MacLaren, Ian ; Pradeep, T. (2006) Investigations of the antibacterial properties of ciprofloxacin@SiO2 Langmuir, 22 (24). pp. 10125-10129. ISSN 0743-7463
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Official URL: http://pubs.acs.org/doi/abs/10.1021/la061411h
Related URL: http://dx.doi.org/10.1021/la061411h
Abstract
The antibacterial activity of ciprofloxacin-encapsulated silica nanoshells synthesized from gold@silica core-shell nanoparticles has been investigated. The minimum inhibitory concentration of the material was found using the agar dilution method, and it showed better antibacterial activity compared to free ciprofloxacin in the case of Escherichia coli DH5a, whereas the same activity was found for Lactococcus lactis MG 1363. Hydrophobicity measurements carried out in an octanol-water mixture suggested that ciprofloxacin@SiO2 is distributed almost equally in the aqueous and nonaqueous phases. The kinetics of the uptake of ciprofloxacin@SiO2 was compared with that of free ciprofloxacin. Fluorescence imaging studies carried out using fluorescein isothiocyanate@SiO2 showed that the nanoshells enter the bacterial cell. The uptake of silica shells has been probed by transmission electron microscopy also.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 27399 |
| Deposited On: | 10 Dec 2010 12:31 |
| Last Modified: | 11 May 2012 11:33 |
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