T-cell prolymphocytic leukemia: a report of two cases with review of literature

Abstract

T-cell Prolymphocytic Leukemia (T-PLL) is a mayure post-thymic T-cell malignancy with aggressive clinical course. The principal disease characteristics are organomegaly, skin lesions and raised lymphocyte counts. We report two cases of T-PLL, T-PLL is a rare T-cell malignancy with characteristics clinical and laboratory features and a poor prognosis. It needs to be differentiated from B-cell prolymphocytic leukemia (B-PLL) and other mature T-cell lymphoproliferative disorders with predominant leukemic pattern. Differentiation can be made by a comprehensive approach taking into account the clinical features, the cell morphology and the immunophenotype of leukemic cells.