Unniraman, Shyam ; Chatterji, Monalisa ; Nagaraja, Valakunja (2002) DNA gyrase genes in mycobacterium tuberculosis: a single operon driven by multiple promoters Journal of Bacteriology, 184 (19). pp. 5449-5456. ISSN 0021-9193
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Official URL: http://jb.asm.org/cgi/content/abstract/184/19/5449
Related URL: http://dx.doi.org/10.1128/JB.184.19.5449-5456.2002
Abstract
The two genes encoding DNA gyrase in Mycobacterium tuberculosis are present next to each other in the genome, with gyrB upstream of gyrA. We show that the primary transcript is dicistronic. However, in addition to the principal promoter, there are multiple weaker promoters that appear to fine-tune transcription. With these and other mycobacterial promoters, we propose consensus promoter sequences for two distinct sigma factors. In addition to this, the gyr genes in M. tuberculosis, as in other species, are subject to autoregulation, albeit with slower kinetics, probably reflecting the slower metabolism of the organism.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Society for Microbiology. |
ID Code: | 26938 |
Deposited On: | 08 Dec 2010 12:58 |
Last Modified: | 17 May 2016 10:13 |
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