Uemura, Isamu ; Bodley, James W. ; Adiga, P. Radhakantha ; Winnick, Theodore (1965) Effect of antibiotics and ribonuclease on polypeptide and protein biosynthesis in different strains of Bacillus brevis Biochimica et Biophysica Acta (BBA)-Nucleic Acids and Protein Synthesis, 95 (1). pp. 86-93. ISSN 0005-2787
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000527...
Related URL: http://dx.doi.org/10.1016/0005-2787(65)90214-5
Abstract
The effect of chloramphenicol, puromycin, and ribonuclease (EC 2.7.7.16) on polypeptide and protein biosynthesis was tested in growing cultures and in cell-free systems of three different strains of Bacillus brevis. With all three strains of the organism, the peptide-synthesizing ability was completely or severely inhibited under conditions which caused total or marked blockage of protein formation. The results support our previous conclusion, based on studies with ribosomal and soluble cellular components, that gramicidins, tyrocidines, and gramicidin S molecules are all synthesized by a pathway which resembles that of protein biogenesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 26831 |
| Deposited On: | 08 Dec 2010 13:07 |
| Last Modified: | 13 May 2011 05:32 |
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