Paul, Saptarshi ; Sen, Asish K. ; Banerjee, Nilima ; Chatterjee, Anadi N. ; Das, Jyotirmoy (1990) Lipid a mutants of Vibrio cholerae: isolation and partial characterization Biochemical and Biophysical Research Communications, 169 (1). pp. 116-122. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(90)91441-T
Abstract
Vibriocholerae mutants resistant to common antibiotics and neutral and anionic detergents were isolated. Analysis of isolated outer membranes revealed a significant deficiency in the acylation of lipid A in the resistant strains. The content of amide-linked and ester-bound fatty acids in the lipid A of the mutant strains compared to that of the wild type was about 50-56% and 29-37% respectively. This defect was specific for lipid A as there was no change in the acylation of phospholipids. The reduction in fatty acid content of lipid A was reflected in the altered endotoxic properties in the mutant strains.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 26530 |
| Deposited On: | 08 Dec 2010 13:36 |
| Last Modified: | 09 Feb 2011 08:03 |
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