Ray, Manju ; Bhaduri, Amar (1974) Udpglucose-4 epimerase from Saccharomyces fragilis: interaction with sugar phosphates at an effector site Biochemical and Biophysical Research Communications, 60 (3). pp. 1081-1089. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(74)90423-9
Abstract
UDP glucose-4 epimerase from Saccharomyces fragilis was found to be activated at low substrate concentrations by some metabolically related sugar phosphates. The stimulation of the enzyme activity showed a sigmoidal response to the increasing concentration of glucose-6 phosphate at a fixed substrate concentration. The activated enzyme was allosterically inhibited by UMP which otherwise acted as a strictly competitive inhibitor for the enzyme. The interaction with sugar phosphates was not accompanied by any change in the aggregation state of the molelcule.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 26441 |
| Deposited On: | 06 Dec 2010 12:32 |
| Last Modified: | 16 May 2011 10:29 |
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