Suryanarayana, T. ; Burma, D. P. (1975) Effects of intercalating agents on the structure of the ribosome Biochemical and Biophysical Research Communications, 65 (2). pp. 708-713. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1016/S0006-291X(75)80203-8
Abstract
Ribosomes treated with an intercalating dye (ethidium bromide or acridine orange) are degraded more rapidly by RNase I than untreated ribosomes. Spermidine or spermine counteracts to great extent the effect produced by the intercalating dye. It appears that the intercalation leads to the 'loosening' of the structure of the ribosome which is also reflected in the decreased inhibitory capacity of the treated ribosomes towards RNase I. Intercalation appears to decrease the affinity of rRNA towards proteins causing the structure of the ribosome to become unfolded.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 26342 |
| Deposited On: | 06 Dec 2010 12:41 |
| Last Modified: | 28 May 2011 04:36 |
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