Roychowdhuri, Sukla ; Banerjee, Asok ; Bhattacharyya, B. (1983) Charge effect on the colchicine binding-site of tubulin Biochemical and Biophysical Research Communications, 113 (2). pp. 384-390. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(83)91738-2
Abstract
Poly (L-lysine) was found to enhance colchicine binding activity of brain tubulin to a several folds. Bases of biological interests that were tested and found to be inactive were spermine, spermidine and even L-lysine. Part of this enhance binding is due to the increase in the affinity of colchicine-tubulin interaction in the presence of poly (L-lysine). Moreover, poly (L-lysine) stabilized the colchicine binding site of tubulin against thermal denaturation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 26177 |
| Deposited On: | 06 Dec 2010 12:58 |
| Last Modified: | 18 May 2011 06:54 |
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