Panda, Subrat K. ; Ramesh, Rajagopal ; Rao, Kanury V. S. ; Gupta, Asha ; Zuckerman, Arie J. ; Nayak, Nabeen C. (1991) Comparative evaluation of the immunogenicity of yeast-derived (recombinant) and plasma-derived hepatitis B vaccine in infants Journal of Medical Virology, 35 (4). pp. 297-302. ISSN 0146-6615
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Official URL: http://www3.interscience.wiley.com/journal/1122051...
Related URL: http://dx.doi.org/10.1002/jmv.1890350416
Abstract
The immunogenicity of plasma-derived (HB Vax, MSD) and recombinant hepatitis B virus (Engerix B, SKF) vaccines was evaluated in infants born to hepatitis B virus carrier mothers. The vaccination was carried out at 1 day, 1 month, and 6 months of age using 10 μ g of the vaccine given intramuscularly. A total of 83/88 (94.3%) and 74/79 (93.6%) of the infants receiving the plasma-derived vaccine and yeast-derived vaccine showed antibody to hepatitis B surface antigen (anti-HBs). None of the maternal factors studied apart from the HBeAg positivity corellated with vaccine failure. The yeast-derived vaccine gives marginally lower antibody titre than the plasma-derived vaccine. The group-specific anti-"a" antibody was less than 10% of the total anti-HBsAg titre. It was observed that the vaccine alone without prior administration of hepatitis B immunoglobulin is effective in perinatal infection.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | HBV; HBV Carriers; HBV DNA; HBV Vaccine; Perinatal Transmission; Anti-"a" Titre |
| ID Code: | 24655 |
| Deposited On: | 29 Nov 2010 10:11 |
| Last Modified: | 10 Jun 2011 06:16 |
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