Enterically transmitted non-A, non-B hepatitis: recovery of virus-like particles from an epidemic in south Delhi and transmission studies in rhesus monkeys

Panda, Subrat K. ; Datta, Rakesh ; Kaur, Jagjit ; Zuckerman, Arie J. ; Nayak, Nabeen C. (1989) Enterically transmitted non-A, non-B hepatitis: recovery of virus-like particles from an epidemic in south Delhi and transmission studies in rhesus monkeys Hepatology, 10 (4). pp. 466-472. ISSN 0270-9139

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Official URL: http://www3.interscience.wiley.com/journal/1121777...

Related URL: http://dx.doi.org/10.1002/hep.1840100411

Abstract

An epidemic of viral hepatitis, serologically characterized as due to non-A, non-B hepatitis, occurred in a village of South Delhi, India, in December, 1986, through January, 1987. Water contaminated with fecal matter was the apparent source of infection. Disease-associated virus-like particles were detected by immune electron microscopy in the feces of three patients within 5 days of illness. The virus-like particles were agglutinated by autologous acute-phase serum but not by convalescent serum. Rhesus monkeys inoculated with particle-containing fecal suspensions developed biochemical and morphologic features of acute, self-limited hepatitis. The findings in the present study and in earlier investigations of sporadic non-A, non-B hepatitis suggest that (i) the epidemic form and a proportion of sporadic cases of this infection in India may be related, both being enterically transmitted and associated with infection by a 27-to 32-nm virus-like particle, (ii) antibody responses to this virus occur early in disease and are transient and (iii) the rhesus monkey may prove to be a suitable model for studies of epidemic non-A, non-B hepatitis.

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Source:Copyright of this article belongs to American Association for the Study of Liver Diseases.
ID Code:24654
Deposited On:29 Nov 2010 10:10
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