Roy, Saikat ; Bhatt, Prashant M. ; Nangia, Ashwini ; Kruger, Gert J. (2007) Stable polymorph of venlafaxine hydrochloride by solid-to-solid phase transition at high temperature Crystal Growth & Design, 7 (3). pp. 476-480. ISSN 1528-7483
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Official URL: http://pubs.acs.org/doi/abs/10.1021/cg0607699
Related URL: http://dx.doi.org/10.1021/cg0607699
Abstract
A novel polymorph of the antidepressant drug venlafaxine hydrochloride (VenHCl) was visualized in thermal microscopy and identified by variable-temperature powder X-ray diffraction at 180-190 °C. Its single-crystal X-ray structure was solved and refined satisfactorily in P21/n space group (form 6, Z' = 2, T = 100 K, R1 = 0.1073). The powder X-ray diffraction pattern and melting point of form 6 are significantly different from the known polymorphs 1-5. Form 6 has a higher melting point and is more stable than marketed drug forms 1 and 2.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 24566 |
| Deposited On: | 29 Nov 2010 08:30 |
| Last Modified: | 04 Mar 2011 05:25 |
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