Nagaraj, Ramakrishnan ; Joseph, Mercy (1993) A convenient method for the synthesis of peptides acylated with palmitic acid specifically at cysteine thiol Bioorganic & Medicinal Chemistry Letters, 3 (6). pp. 1025-1028. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/S0960-894X(00)80280-2
Abstract
Acylation of a cysteine containing peptide with palmitoyl chlroide, when attached to a solid support, followed by acidolytic cleavage of the peptide from the resin, to generate the fatty acylated peptide was explored. Our results indicate that this is a convenient method to synthesize peptides specifically acylated at the thiol group of cysteine. Acylation of a cysteine containing peptide with palmitoyl chloride, when attached to a solid support, followed by acidolytic cleavage of the peptide from the resin, to generate the fatty acylated peptide is a convenient method to synthesize peptides specifically acylated at the thiol group of cysteine.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 24003 |
| Deposited On: | 01 Dec 2010 12:46 |
| Last Modified: | 25 Jan 2011 08:36 |
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