Krishnakumari, Viswanatha ; Rangaraj, Nandini ; Nagaraj, Ramakrishnan (2009) Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3 Antimicrobial Agents and Chemotherapy, 53 (1). pp. 256-260. ISSN 0066-4804
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Official URL: http://aac.asm.org/cgi/content/abstract/53/1/256
Related URL: http://dx.doi.org/10.1128/AAC.00470-08
Abstract
The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD-1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD-1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| ID Code: | 23993 |
| Deposited On: | 01 Dec 2010 12:48 |
| Last Modified: | 17 May 2016 07:46 |
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