Chadha, A. ; Madyastha, K. Madhava (1984) Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes Xenobiotica, 14 (5). pp. 365-374. ISSN 0049-8254
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Official URL: http://informahealthcare.com/doi/abs/10.3109/00498...
Related URL: http://dx.doi.org/10.3109/00498258409151425
Abstract
1. Metabolites isolated from the urine of rats after oral administration of geraniol (I) were: geranic acid (II), 3-hydroxy-citronellic acid (III), 8-hydroxy-geraniol (IV), 8-carboxy-geraniol (V) and Hildebrandt acid (VI). 2. Metabolites isolated from urine of rats after oral administration of linalool (VII) were 8-hydroxy-linalool (VIII) and 8-carboxy-linalool (IX). 3. After three days of feeding rats with either geraniol or linalool, liver-microsomal cytochrome P-450 was increased. Both NADH- and NADPH-cytochrome c reductase activities were not significantly changed during the six days of treatment. 4. Oral administration of these two terpenoids did not affect any of the lung-microsomal parameters measured.
Item Type: | Article |
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Source: | Copyright of this article belongs to Informa Healthcare. |
ID Code: | 23479 |
Deposited On: | 25 Nov 2010 13:15 |
Last Modified: | 10 Jun 2011 06:41 |
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