Biocatalyst-mediated expansion of ring D in azadirachtin, a potent insect antifeedant from Azadirachta indica

Madyastha, K. M. ; Venkatakrishnan, K. (1999) Biocatalyst-mediated expansion of ring D in azadirachtin, a potent insect antifeedant from Azadirachta indica Tetrahedron Letters, 40 (28). pp. 5243-5246. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(99)00992-2

Abstract

A microorganism identified as Nocardia Sp.capable of converting azadirachtin 1 into three metabolites, viz. 3-deacetylazadirachtin 2, 1-detigloyl-3-deacetyl-azadirachtin-1-ene-3-one 3 and 1-detigloyl-3-deacetyl-11,19-deoxa-12,19-oxa-11-oxo-azadirachtin-1-ene-3-one 4, has been isolated. This is the first report on the functionalization of azadirachtin using biocatalysts wherein two novel, hitherto unknown metabolites have been isolated and characterized.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Azadirachta Indica; Azadirachtin; Biocatalyst; Nocardia Sp; α,β-unsaturated Ketone; α-keto-δ-lactone
ID Code:23477
Deposited On:25 Nov 2010 13:15
Last Modified:10 Jun 2011 06:24

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