Owais, Mohd. ; Ahmed, I. ; Krishnakumar, B. ; Jain, R. K. ; Bachhawat, B. K. ; Gupta, C. M. (1993) Tuftsin-bearing liposomes as drug vehicles in the treatment of experimental aspergillosis FEBS Letters, 326 (1-3). pp. 56-58. ISSN 0014-5793
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...
Related URL: http://dx.doi.org/10.1016/0014-5793(93)81760-W
Abstract
Encapsulation of amphotericin B in tuftsin-bearing liposomes greatly increased its efficacy in treatment of human aspergillosis in mice. Also, the drug efficacy was significantly increased by pretreating the animals with drug-free tuftsin-bearing liposomes. These results demonstrate that macrophage activation can considerably enhance the therapeutic efficacy of antifungal drugs, like amphotericin B.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Biochemical Societies. |
| Keywords: | Tuftsin; Macrophage Activation; Fungal Infection; Liposome; Amphotericin B |
| ID Code: | 2181 |
| Deposited On: | 08 Oct 2010 07:38 |
| Last Modified: | 16 May 2016 13:12 |
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