Ghaisas, Sadhana ; Saranath, Dhananjaya ; Deo, Madhav G. (1989) ICRC mouse with congenital mega-esophagus as a model to study esophageal tumorigenesis Carcinogenesis, 10 (10). pp. 1847-1854. ISSN 0143-3334
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Official URL: http://carcin.oxfordjournals.org/cgi/content/abstr...
Related URL: http://dx.doi.org/10.1093/carcin/10.10.1847
Abstract
ICRC mouse, an inbred strain, developed at the Cancer Research Institute, Bombay, exhibits mega-esophagus with markedly hyperplastic mucosa. Diethylnitrosamine (DEN) when given in drinking water at the dose of 4 mg/kg body weight/day, induced esophageal papillomas consistently in 100% of the animals, in a short period of 12 weeks. Further, tumors were produced, even at a very low cumulative dose of 28 mg/kg body weight. Development of the esophageal papillomas was dose dependent. DEN even induces esophageal tumors transplacentally in the ICRC F1 progeny. Tobacco acts predominantly as a promoter in this system. ICRC mouse thus provides a much needed animal model to study esophageal tumorigenesis, including the two-stage carcino genesis. An interesting feature of the study is that initiation could be induced by exposure to low doses of DEN in the intra-uterine life. Tumors develop in such F1 animals only if they are fed tobacco, a predominant promoter, post-natally.
Item Type: | Article |
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Source: | Copyright of this article belongs to Oxford University Press. |
ID Code: | 21746 |
Deposited On: | 22 Nov 2010 10:53 |
Last Modified: | 17 May 2016 05:55 |
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