Equine luteinizing hormone possesses follicle-stimulating hormone activity in hypophysectomized female rats

Moudgal, N. R. ; Papkoff, H. (1982) Equine luteinizing hormone possesses follicle-stimulating hormone activity in hypophysectomized female rats Biology of Reproduction, 26 (5). pp. 935-942. ISSN 0006-3363

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Official URL: http://www.biolreprod.org/content/26/5/935.abstrac...

Related URL: http://dx.doi.org/10.1095/biolreprod26.5.935

Abstract

The ability of equine luteinizing hormone (eLH) to promote follicular growth and maturation in hypophysectomized rats has been assessed. A single injection of equine LH has been shown to promote the growth of a large number of antral and preovulatory follicles. In addition, equine LH markedly increased serum estrogen levels and uterine weight. Furthermore, equine LH, like equine chorionic gonadotropin (eCG; PMSG) was able to significantly enhance the incorporation of [3H]thymidine into ovarian DNA, an activity shown to be specific to hormones having follicle-stimulating hormone (FSH) activity. Equine LH treated with an FSH antibody immunoaffinity column to remove any possible contamination still exhibited the above activity, demonstrating that the FSH activity is intrinsic to the eLH molecule. Equine LH has also been shown to be capable of inducing LH receptors in granulosa cells of ovaries of hypophysectomized rats, an activity specific to FSH-like hormones. From the doses required of eLH and the degree of response observed, it is concluded, however, that eLH in the hypophysectomized rat is less active than eCG as an FSH.

Item Type:Article
Source:Copyright of this article belongs to Society for the Study of Reproduction.
ID Code:21648
Deposited On:22 Nov 2010 11:36
Last Modified:17 May 2016 05:50

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