Packing of aromatic rings against tryptophan residues in proteins

Samanta, Uttamkumar ; Pal, Debnath ; Chakrabarti, Pinak (1999) Packing of aromatic rings against tryptophan residues in proteins Acta Crystallographica Section D, 55 (8). pp. 1421-1427. ISSN 0907-4449

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The geometry of the interaction of the aromatic side chains of phenylalanine (Phe), tyrosine (Tyr), tryptophan (Trp) and histidine (His) with the indole ring of Trp has been analyzed using the structures in the Protein Data Bank in order to understand the dependence of the packing behaviour on the size and chemical nature of the aromatic rings. The Phe ring prefers to interact either perpendicularly, with its edge pointing towards the Trp face, or in an offset-stacked arrangement. The edge-to-face motif is typical of a Trp-Trp pair. While parallel stacking is the dominant feature of Trp-His interaction, Tyr packs in a more uniform manner around Trp with a higher than expected occurrence at the edge and a few cases of possible OH-Π interaction.

Item Type:Article
Source:Copyright of this article belongs to International Union of Crystallography.
Keywords:Aromatic-aromatic Interactions; Molecular Recognition; OH-Π Interactions; Tryptophan
ID Code:21435
Deposited On:22 Nov 2010 11:27
Last Modified:17 May 2016 05:39

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