A comparison of two popular statistical methods for estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences

Basu, Analabha ; Majumder, Partha P. (2003) A comparison of two popular statistical methods for estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences Journal of Genetics, 82 (1-2). pp. 7-12. ISSN 0022-1333

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Official URL: http://www.ias.ac.in/jgenet/Vol82Nos1and2/7.pdf

Related URL: http://dx.doi.org/10.1007/BF02715874

Abstract

We have compared two statistical methods of estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences, which have been proposed by Templeton (1993) and Bandeltet al. (1995). Monte-Carlo simulations were used for generating DNA sequence data. Different evolutionary scenarios were simulated and the estimation procedures were evaluated. We have found that for both methods (i) the estimates are insensitive to demographic parameters and (ii) the standard deviations of the estimates are too high for these methods to be reliably used in practice.

Item Type:	Article
Source:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	Coalescence; Monte-carlo Simulation; Evolution
ID Code:	21375
Deposited On:	20 Nov 2010 13:01
Last Modified:	17 May 2016 05:35

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