Iyengar, Sudha ; Hamman, Richard F. ; Marshall, Julie A. ; Majumder, Partha P. ; Ferrell, Robert E. ; Rao, D. C. ; Vogler, G. P. (1989) On the role of vitamin D binding globulin in glucose homeostasis: results from the San Luis Valley diabetes study Genetic Epidemiology, 6 (6). pp. 691-698. ISSN 0741-0395
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/gepi.13...
Related URL: http://dx.doi.org/10.1002/gepi.1370060606
Abstract
Several studies have reported association between noninsulin-dependent diabetes mellitus and GC, the vitamin D binding protein of human plasma, with the GC 1 allele in significant excess among diabetics. Additionally, there is a considerable body of animal data suggesting that vitamin D has a significant impact on insulin secretion. Examination of the insulin levels in Dogrib Indians showed that the lowest levels of fasting insulin were associated with the GC 1F-1F genotype. The present study examined levels of glucose, C-peptide, and insulin at fasting and 1 hr and 2 hr following a 75 g oral glucose challenge, in a population of Hispanic-Americans and Anglos in the San Luis Valley of southern Colorado. The sample comprised a total of 468 individuals with normal glucose tolerance. Of these, 289 were Anglos and 179 were Hispanic-Americans. An analysis of covariance was performed to determine the effect of the GC genotypes on mean levels of the primary variables-glucose, C-peptide, and insulin-and a secondary variable-insulinogenic index adjusting for the covariates age, body mass index (BMI), gender, and ethnicity. The analyses revealed that there is a significant difference in mean levels of glucose at fasting (F value = 2.46; P = 0.033) among the GC genotypes in the sample. Additionally, the differences in mean levels of 1 hr postprandial glucose among the GC genotypes although not significant at a 5% level, were significant at the 10% level. No other significant phenotypic effects were observed. These analyses, are not in concordance the results of an earlier study, where lower fasting insulin was associated with the GC 1F-1F genotype.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
Keywords: | Diabetes mellitus; Noninsulin-dependent Diabetes mellitus; Insulin; C-peptide; Group-specific Component; Polymorphism |
ID Code: | 21347 |
Deposited On: | 20 Nov 2010 13:04 |
Last Modified: | 06 Jun 2011 09:23 |
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