Seethalakshmi, S. ; Appaji Rao, N. (1979) Regulation of the activity of mung bean (Phaseolus aureus) glutamine synthetase by amino acids and nucleotides Archives of Biochemistry and Biophysics, 192 (2). pp. 588-597. ISSN 0003-9861
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000398...
Related URL: http://dx.doi.org/10.1016/0003-9861(79)90312-6
Abstract
The activity of glutamine synthetase isolated from the germinated seedlings of Phaseolus aureus was regulated by feedback inhibition by alanine, glycine, histidine, AMP, and ADP. When glutamate was the varied substrate, alanine, histidine, and glycine were partial noncompetitive, competitive, and mixed-type inhibitors, respectively. The type of inhibition by these amino acids was confirmed by fractional inhibition analysis. The adenine nucleotides, AMP and ADP, completely inhibited the enzyme activity and were competitive with respect to ATP. Multiple inhibition analyses revealed the presence of separate and nonexclusive binding sites for the amino acids and mutually exclusive sites for adenine nucleotides. Cumulative inhibition was observed with these end products.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 21226 |
| Deposited On: | 20 Nov 2010 09:15 |
| Last Modified: | 12 May 2011 12:19 |
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