Differential evolution of coding and non-coding sequences in related vertebrates: implications in probe design

Abstract

Considerable progress has been made in divulging the genome organization of different species by using DNA probe basede on coding and non coding sequences. This encompasses the individualization of the genome to assess the genetic structure of a population and reproductive behaivour of animals and birds as well as phylogenetic relationshipof different species at a supramolecular level. Literature survey shows that these sequences originate and undergo evolutionary metamorphosis at the molecular level and are useful as powerful genetic markers in a wide range of species to address a variety of issues related to biology and medicine including forensic sciences. In this paper, we elaborate organizational and evolutionary aspects of some coding and non coding sequences and their powerful use as genetic markers amongst related vertebrate species. The technical procedures, prospects and possible pitfalls are also covered to facilitate the conceptual understanding of the fast emerging technology.