Radical-induced opening of trisubstituted epoxides: application in the synthesis of C1-C12 segment of epothilones

Chakraborty, T. K. ; Dutta, S. (1998) Radical-induced opening of trisubstituted epoxides: application in the synthesis of C1-C12 segment of epothilones Tetrahedron Letters, 39 (1-2). pp. 101-104. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(97)10442-7

Abstract

Diastereo- and regioselective opening of a trisubstituted epoxy ketone at the more substituted carbon using samarium(II) iodide presents an alternate approach to the C5-C7 aldol moiety with β-hydroxyketo framework in the stereoselective synthesis of C1-C12 segment of epothilones.

Item Type:Article
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ID Code:20615
Deposited On:20 Nov 2010 13:51
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