Synthesis of chiral α-amino acids

Chakraborty, Tushar K. ; Ghosh, Animesh (2002) Synthesis of chiral α-amino acids Tetrahedron Letters, 43 (52). pp. 9691-9693. ISSN 0040-4039

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Official URL: http://dx.doi.org/10.1016/S0040-4039(02)02433-4

Related URL: http://dx.doi.org/10.1016/S0040-4039(02)02433-4

Abstract

A novel method for the synthesis of chiral α-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the α-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:α-Amino Acids; Hofmann Rearrangement; Oxazolidinone; Evans' Reaction
ID Code:20592
Deposited On:20 Nov 2010 13:54
Last Modified:22 May 2011 15:13

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