Studies directed towards the synthesis of antascomicin A: stereoselective synthesis of the C1-C21 fragment of the molecule

Chakraborty, Tushar Kanti ; Mohan, Bajjuri Krishna (2006) Studies directed towards the synthesis of antascomicin A: stereoselective synthesis of the C1-C21 fragment of the molecule Tetrahedron Letters, 47 (29). pp. 4999-5002. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2006.05.113

Abstract

A stereoselective synthesis of the C1-C21 fragment of the non-immunosuppressive immunophilin-binding natural product, antascomicin A was achieved using, as key steps, highly stereoselective Aldol reactions to build the C1-C17 fragment and a Nozaki-Hiyama-Kishi reaction to couple it with the remaining C18-C21 moiety.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Antascomicin; Immunosuppressant; FKBP12 Binding Ligand; Takai Reaction
ID Code:20512
Deposited On:20 Nov 2010 14:23
Last Modified:01 Feb 2011 08:47

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