Chakraborty, Tushar Kanti ; Koley, Dipankar ; Ravi, Rapolu ; Krishnakumari, Viswanatha ; Nagaraj, Ramakrishnan ; Kunwar, Ajit Chand (2008) Synthesis, conformational analysis and biological studies of cyclic cationic antimicrobial peptides containing sugar amino acids Journal of Organic Chemistry, 73 (22). pp. 8731-8744. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo801123q
Related URL: http://dx.doi.org/10.1021/jo801123q
Abstract
Sugar amino acid based 24-membered macrocyclic C2-symmetric cationic peptides were designed and synthesized. The cationic group was introduced in the sugar amino acids. The conformation of these cyclic compounds was ascertained through NMR techniques, which proved they were amphipathic in nature. All the compounds were bacteriolytic, showed good activity against the Gr+ve and Gr-ve bacteria, and exhibited low hemolytic activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 20434 |
| Deposited On: | 20 Nov 2010 14:31 |
| Last Modified: | 02 Feb 2011 08:41 |
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