Stabilization of β-hairpin structures via inter-strand ∏-∏ and hydrogen bond interactions in α-, β-, γ-hybrid peptides

Chakraborty, Tushar K. ; Srinivasa Rao, K. ; Udaya Kiran, M. ; Jagadeesh, B. (2009) Stabilization of β-hairpin structures via inter-strand ∏-∏ and hydrogen bond interactions in α-, β-, γ-hybrid peptides Tetrahedron Letters, 50 (30). pp. 4350-4353. ISSN 0040-4039

Preview

PDF - Publisher Version
215kB

Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2009.05.024

Abstract

Synthesis and conformational studies of α-, β-, γ-hybrid peptides containing a pyrrole amino acid (Paa, 1) and a furan amino acid (Faa, 2), namely Boc-β-Phe-Faa-D-Pro-Gly-Paa-β-HGly-Faa-OMe (3) and Boc-Paa-β-Phe-Faa-D-Pro-Gly-Paa-β-HGly-Faa-OMe (4), were carried out and they adopt β-hairpin structures stabilized via inter-strand ∏-∏ and hydrogen bonding interactions.

Item Type:	Article
Source:	Copyright of this article belongs to Elsevier Science.
Keywords:	Pyrrole Amino Acid; Furan Amino Acid; Peptidomimetics; β-hairpin
ID Code:	20428
Deposited On:	20 Nov 2010 14:31
Last Modified:	17 May 2016 04:46

Repository Staff Only: item control page