Sandbhor, Uday ; Kulkarni, Pallavi ; Padhye, Subhash ; Kundu, Gopal ; Mackenzie, Grahame ; Pritchard, Robin (2004) Antimelanomal activity of the copper(II) complexes of 1-substituted 5-amino-imidazole ligands against B16F10 mouse melanoma cells Bioorganic & Medicinal Chemistry Letters, 14 (11). pp. 2877-2882. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2004.03.041
Abstract
The copper complexes of 5-amino-imidazole ligands were prepared and characterized by various spectroscopic techniques. The ligand geometry around the copper(II) centre is square pyramidal based on N2O2 donor atoms and a coordinated water molecule at the apex. Single crystal X-ray structures were determined for both ligands. Ligands and copper complexes exhibited dose-dependent antiproliferative effects on the growth of B16F10 melanoma cells line but lower IC50 values were observed for the copper complexes. The copper complexes of 5-amino-imidazole ligands were prepared and characterized by various spectroscopic techniques. Ligands and copper complexes exhibited dose-dependent antiproliferative effects on the growth of B16F10 melanoma cells line but lower IC50 values were observed for the copper complexes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Copper Complexes; Amino-imidazole; Antimelanomal Compounds; X-ray Structure |
| ID Code: | 19970 |
| Deposited On: | 20 Nov 2010 15:14 |
| Last Modified: | 04 Jun 2011 08:51 |
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