Protein A - a new ligand for human C-reactive protein

Das, Tanusree ; Mandal, Chhabinath ; Mandal, C. (2004) Protein A - a new ligand for human C-reactive protein FEBS Letters, 576 (1-2). pp. 107-113. ISSN 0014-5793

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00145...

Related URL: http://dx.doi.org/10.1016/j.febslet.2004.08.072

Abstract

Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an extended definition of CRP. Protein A binding may impart immunomodulatory roles of CRP in combating microorganisms or other foreign materials.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:C-reactive Protein; Glycosylated Human C-reactive Protein; Molecular Variant; Phosphorylcholine; Protein A Binding; Staphylococcus Aureus Cell-surface Protein A
ID Code:19367
Deposited On:22 Nov 2010 12:43
Last Modified:17 May 2016 03:56

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