Chowdhury, Suchandra ; Mandal, Chitra (2009) O-acetylated sialic acids: multifaceted role in childhood acute lymphoblastic leukaemia Biotechnology Journal, 4 (3). pp. 361-374. ISSN 1860-6768
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/biot.20...
Related URL: http://dx.doi.org/10.1002/biot.200800253
Abstract
Childhood acute lymphoblastic leukaemia (ALL), a malignant transformation of the lymphoblasts, is highly responsive to chemotherapy. However, due to certain inadequacy in detection of minimal residual disease (MRD), relapse is a common phenomenon. To address this question, the present review deals with the induction of an unique O-acetyl derivative of sialic acid on a few disease-associated glycoproteins and glycolipids at the onset of childhood ALL, a finding of our group in the last decade. This information has been successfully utilized for diagnosis and prognosis of the disease. Existing literature is included for comparison. Additionally, cell surface overexpression of 9-O-acetylated sialoglycoproteins and antibodies against them present in patients' sera aid the survival of the malignant lymphoblasts and suggest a multifaceted role played by these molecules. Taken together, monitoring these molecules helps not only in unravelling the biology of this paediatric malignancy but also in personalizing the treatment strategies for the betterment of the patient population.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
Keywords: | Achatinin-H; Childhood Acute Lymphoblastic Leukaemia; Minimal Residual Disease; 9-O-acetylated Sialic Acids |
ID Code: | 19333 |
Deposited On: | 22 Nov 2010 12:46 |
Last Modified: | 28 Feb 2011 08:48 |
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