Adhikari, Jukta ; Lahiri Majumder, Arun (1983) Differences in thermal stability of the fetal and adult brain myo-inositol-1-phosphate synthase: probable involvement of NAD FEBS Letters, 163 (1). pp. 46-49. ISSN 0014-5793
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...
Related URL: http://dx.doi.org/10.1016/0014-5793(83)81159-4
Abstract
L-myo-inositol-1-phosphate synthase (EC 5.5.1.4) from mammalian fetal and adult brain differ considerably with respect to their stability towards different temperatures between 25-65°C. This property has been found to be associated with the presence of the synthase co-factor, NAD, bound to the enzyme protein. The lower thermal stability of the fetal enzyme increases in presence of added NAD (0.8 mM) whereas the higher thermal stability of the adult brain enzyme declines when NAD is specifically removed from the enzyme.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Biochemical Societies. |
| Keywords: | Nositol Synthase; Thermal Stability; Bound NAD; Mammalian Brain; Human Fetus |
| ID Code: | 19213 |
| Deposited On: | 23 Nov 2010 13:18 |
| Last Modified: | 17 May 2016 03:48 |
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