Ghosh, Shyamasree ; Bandyopadhyay, Suman ; Pal, Santanu ; Das, Benubrata ; Bhattacharya, Dilip K. ; Mandal, Chitra (2005) Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia British Journal of Haematology, 128 (1). pp. 35-41. ISSN 0007-1048
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...
Related URL: http://dx.doi.org/10.1111/j.1365-2141.2004.05256.x
Abstract
Disease-specific over-expression of 9-O-acetylated sialoglycoconjugates (9-O-AcSGs) on peripheral blood mononuclear cells (PBMC) of children with acute lymphoblastic leukaemia (ALL, PBMCALL) has been demonstrated using a lectin, Achatinin-H, with specificity towards 9-O-AcSAα2-6GalNAc. This study investigated the contributory role of 9-O-AcSGs induced on PBMCALL. Stimulation of PBMCALL with Achatinin-H through 9-O-AcSGs led to a lymphoproliferative response with a significantly increased interferon-γ (IFN-γ) production when compared with unstimulated cells as demonstrated by enzyme-linked immunosorbent assay and mRNA expression. Under identical conditions, PBMCALL ablated of O-acetylations did not respond to such stimulation. In summary, it may be concluded that stimulation of over-expressed 9-O-AcSGs regulate signalling for proliferation, leading to the release of IFN-γ. Controlled expression of these molecules may be exploited as potential targets for therapy, promising beneficial effects to children with ALL.
Item Type: | Article |
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Source: | Copyright of this article belongs to British Society for Haematology. |
Keywords: | Childhood Acute Lymphoblastic Leukaemia; Achatinin-H; O-acetylated Sialic Acid Binding Lectin; 9-O-acetylated Sialoglycoconjugates; Interferon Gamma |
ID Code: | 19122 |
Deposited On: | 25 Nov 2010 14:17 |
Last Modified: | 17 May 2016 03:44 |
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