Soni, Madhusudan ; Madurantakan, Mukundan ; Krishnaswamy, Kamala (1998) Glutathione S-transferase Mu (GST Mu) deficiency and DNA adducts in lymphocytes of smokers Toxicology, 126 (3). pp. 155-162. ISSN 0300-483X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S03004...
Related URL: http://dx.doi.org/10.1016/S0300-483X(98)00010-9
Abstract
The effect of smoking on DNA adduct formation in lymphocytes was analysed in individuals with low (deficient) and high (non-deficient) glutathione S-transferase (class Mu) activity. DNA adduct levels in lymphocytes were determined by the highly sensitive nuclease P1-enhanced 32P-postlabeling assay. The lymphocyte DNA adducts/108 nucleotides of smokers deficient in glutathione S-transferase Mu activity (n=12) were significantly higher than those of smokers non-deficient (n=9) in glutathione S-transferase Mu activity. The DNA adduct levels of the lymphocytes inversely correlated with glutathione S-transferase Mu activity. A correlation was found between DNA adduct levels and daily cigarette consumption. Results of the present study suggest that individuals deficient in glutathione S-transferase Mu activity may be at greater risk of DNA damage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Cigarette Smoking; DNA Adduct Formation; Lymphocytes; Glutathione S-transferase (class Mu) |
| ID Code: | 18664 |
| Deposited On: | 17 Nov 2010 12:37 |
| Last Modified: | 23 Feb 2011 10:50 |
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