Inhibition of B(a)P induced strand breaks in presence of curcumin

Polasa, K. ; Naidu, A. N. ; Ravindranath, I. ; Krishnaswamy, K. (2004) Inhibition of B(a)P induced strand breaks in presence of curcumin Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 557 (2). pp. 203-213. ISSN 1383-5718

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S13835...

Related URL: http://dx.doi.org/10.1016/j.mrgentox.2003.10.016

Abstract

Incidence of cancer at different sites may be related to oxidative damage to host genome by genotoxicants. These oxidative actions may be modified by phytochemicals present in foods. The non-nutritive dietary constituents which possess antimutagenic property appear to be promising chemopreventive agents. This study reports the protective effect of curcumin on B(a)P induced DNA damage in human peripheral blood lymphocyte cells. The study group consisted of 10 male smokers, 10 non-smokers and 10 non-smoking females aged between 25 and 45. The DNA damage was assessed using comet assay. In all the groups curcumin showed a dose-dependent inhibitory effect. The effect appeared to be sex dependent. There was no correlation between DNA damage and GST-Mu levels and levels of micronutrients namely Vitamins A, E and beta carotene. The results of this study are in line with our earlier observations on turmeric/curcumin as a potential chemopreventer.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:DNA Damage; Protective Effect of Curcumin; Strand Breaks
ID Code:18656
Deposited On:17 Nov 2010 12:38
Last Modified:04 Jun 2011 08:45

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