Ascribing functions to the lamin B receptor

Kasbekar, Durgadas P. (1999) Ascribing functions to the lamin B receptor Journal of Biosciences, 24 (3). pp. 401-408. ISSN 0250-5991

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This article reviews the research on the inner nuclear membrane protein lamin B receptor (LBR). It focuses on the biochemical and immunological evidence for an LBR; the cloning of chicken, rat and human LBR cDNAs and genomic sequences; the lamin B-, chromatin-, DNA- and NLS-binding properties of the N-terminal domain and its phosphorylation by different kinases; the sterol C-14 reductase activity of the C-terminal domain; the use of yeast two-hybrid screens and co-immunoprecipitation to identify interacting proteins; and the probing of nuclear assembly and disassembly in living cells with LBR-GFP fusion proteins. The article concludes by considering a scenario whereby LBR levels might even regulate gene expression.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Nuclear Envelope; Sterol Biosynthesis; Neurospora; Membrane-heterochromatin Interaction
ID Code:18385
Deposited On:17 Nov 2010 09:19
Last Modified:04 Jun 2011 04:27

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